Hi Everyone
I hope all is well
This is a the next post of 2020. It is from my friend and colleague Tom Wing all around Dementia and Physical Activity.
Hope all my readers you find this useful :)
Enjoy!
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Hi Everyone,
Thank
you for taking the time read this post!
I
am currently studying MSc Physiotherapy (Pre-registration) at Teesside University,
following graduating top of my class with 1st class honours in Sport’s Therapy
and Rehabilitation. Since I have become a fully accredited member of the British Association of Sport Rehabilitators and
Trainers (BASRaT) and was present with the GrayBrook award in 2019 for the
highest academic degree classification for all Sports Rehabilitation courses in
the United Kingdom. I would like to state I
am NOT an expert on Dementia care but as a healthcare
professional I am an advocate of Physical Activity and Exercise.
If
anyone would like guidance on Physical Activity and Exercise, please contact me
via my company’s (Teesside Athletic Academy) Facebook or Instagram page. The links are at the end of the article
Introduction
The word dementia originates from the Latin
words – de and mens - translating as out of mind, leading to the development
cultural stigma surrounding the illness (Mukadam,
and Livingston 2012). Subsequently the loss of independence and autonomy
experienced by patients with dementia (PwD) maybe due to the combination of cultural
stigma and the illness (Mukadam, and Livingston,
2012; Yates et al., 2019). Dementia was referred historically to
as a clinical syndrome affecting the brain and manifesting as a reduced
cognitive status, typically within the elderly demographic (Breitner, 2006; Mukadam, and Livingston, 2012).
This led some researchers to infer the pathology
is a mental health disorder, adding to the aforementioned cultural stigma surrounding the disorder (Mukadam, and Livingston, 2012). The illness should now be recognized as a neurocognitive condition (Palm et
al., 2016). Epidemiological data suggests the condition is the
greatest international challenge to 21st century health/social care and due to the ageing populace, prevalence is set to
triple by 2050 (Mukadam, and Livingston, 2012; Livingston et al., 2017; Beydoun, and Kivimaki, 2019; World Health Organization, 2019). A systematic review by Suijkerbuijk
et al., (2019), expresses the need to develop interventions
promoting independence and well-being in PwD. The
Lancet Commission for dementia care substantiates
this, adding despite the underlying neurological condition remaining
largely uncurable, the clinical manifestations may be modifiable with excellent
care (Livingston et al., 2017). Physical
Activity and Exercise maybe one such intervention.
Prevention
of Mild Cognitive Impairment and Dementia
It is well documented
increased exercise and physical activity in
the older population positively impact upon falls, mood, function, mortality
and combats risk factors of dementia - diabetes, hypertension, and obesity (Blake et al., 2009; Almeida et al.,
2014; de Labra et al., 2015; Livingston et
al., 2017; Blond et al., 2019; de Souto Barreto et al., 2019;
Ekelund et al., 2019; GarcĂa-Hermoso et
al., 2020). A meta-analysis of prospective
cohort studies (n=33,816) by Sofi et
al., (2011) conducted high
levels physical activity and exercise had a significant effect in mitigating cognitive
decline in PwD. As explored throughout
the Lancet Commission adults who perform regular physical activity and exercise
display a greater prospect of maintaining cognitive function than those that do
not, appearing to have an inverse relationship with rates of the cognitive
decline or dementia (Livingston et al., 2017). The
effectiveness of physical activity and exercise
in combating cognitive decline is substantiated by a meta-analysis (n=163,797),
suggesting that rates of dementia are lower in persons who perform high levels
of physical activity and exercise (Hamer and Chida, 2009). Due to the lack of randomized
controlled trials (RCT) within the meta-analyses both Hamer and Chida, (2009); Sofi
et al., (2011) have low internal validity. Nevertheless, clinical
relevance may still be taken from Hamer and Chida, (2009); Sofi et al., (2011)
due to the large sample size within reducing
the impact of within-subject variation, thus increasing the reliability of the
results (Hopkins 2000; Hopkins 2019).
The
Effect of Physical Activity and Exercise on Mild Cognitive Impairment
As discussed through the Lancet Commission
there is a developing body of research suggesting exercise and physical
activity may be beneficial for suffers of the mild cognitive impairment (Livingston et al., 2017).
Despite this, there is conflicting evidence documenting the effectiveness
of exercise and physical activity as an intervention to improve cognition in an
older demographic. Furthermore, the National
Institute for Health and Care Excellence (NICE)
Guidelines, (2018) only recommended exercise for dementia patients with
disturbed sleep. A Cochrane review of 12 studies (n=754) reported that
there is no evidence to supporting the utilization of aerobic exercise as an
intervention to improve cognition in healthy elderly adults (Young et al., 2015).
A meta-analysis by Kelly et al., (2014),
of 25 RCT’s corroborate findings of the Cochrane
review, suggesting the evidence
surrounding aerobic exercise to improve cognition to be inconclusive. As
the meta-analysis has a high number of RCT’s the meta-analysis has an exceptionally high
internal validity as RCT’s are considered to be level 1 evidence for
evidence-based practice (Hshieh et al., 2015). Despite this,
aerobic exercise may be an effective intervention for elderly adults suffering
with cognition impairments such as dementia. A meta-analysis
of 11 papers by Zheng et al., (2016) found aerobic interventions
were effective in improving global cognition in the elderly populace with
cognitive impairment. This is validated by a recent meta-analysis of 5 RCT’s by Zhu et al., (2020) discovered
aerobic dance had positive effects on global cognition (Mean difference=1.43;
95% CI: [0.59, 2.27]; p=0.0009). Due to all the studies within the
meta-analysis being RTC’s, Zhu et al., (2020) has a high internal
validity. Despite this, as aerobic dance is an emerging intervention to improve
cognition there is a limited number of studies available for analysis, reducing
external validly. Further research is needed to verify finding by Zhu et
al., (2020) before aerobic dance can be utilized as intervention.
Nonetheless, this adds to the expanding body of research supporting the use of
aerobic activity by healthcare professionals to improve cognition in elderly
patients suffering with cognitive deficiency.
The
Effect of Physical Activity and Exercise on Dementia
A Cochrane review of 17 trials studies (n=1067)
found no evidence exercise improved cognitive function in PwD and deemed the
evidence to be very low quality (Forbes et al., 2015). Studies within
the review are dated pre 2013, more contemporary evidence endorses the
utilization of exercise and physical activity to enhance cognition. Subsequent
systematic-reviews/meta-analyse investigating physical actively and exercise as
an intervention in patients living with Alzheimer’s disease and dementia, thus disputing
the findings of Cochrane review (Groot et al., 2016; Karssemeijer et
al., 2017; Du et al., 2018; Jia et al., 2019; Law et al., 2020).
The Lancet Commission concluded, exercise programs for PwD suffering mild to
moderate dementia is well accepted with high-intensity exercise groups well
evidenced among-st Alzheimer’s suffers (Livingston et
al., 2017). A systematic review of 50 papers (n=5099)
by Law et al., (2020), uphold findings by the Lancet Commission,
inferring there is moderate evidence supporting the use of aerobic exercise at
moderate to high intensity to improve global cognition in PwD. Nevertheless, Egger’s
regression asymmetry test discovered publication bias to be present among-st studies within the review, hence
impacting upon the validity of the results (Hussain et al., 2011). Healthcare professionals may still take clinical
relevance from the Lancet Commission and Law et al., (2020) as it
highlights the importance of reaching aerobic threshold during high intensity
exercise sessions to facilitate hippocampal
neurogenesis (Erickson et al., 2011; Erickson, Gildengers and Butters,
2013; Livingston et al., 2017).
Manipulation of Training
Variables
The manipulation of other
training variables - such as frequency, session duration and length of
intervention may also have beneficial impacts on cognition as well as
intensity. A meta-analysis of 13 studies by Jia et al., (2019) reports
lower frequency (≤3 sessions a week) and sessions duration (≤30-minute)
of moderate to high intensity sessions to have the greatest impact on cognition
in patients suffering from Alzheimer’s. Furthermore, interventions longer than 16 weeks appear to have more
beneficial impacts on cognition. This is substantiated by Law et al.,
(2020), concluding if the total training duration is greater than 24-hours
the effectiveness of intervention may increase. Nonetheless, Jia et al., (2019) suggests due to the
variation in exercise interventions, more high-quality RCT’s are needed to
corroborate these findings. Healthcare professionals therefore maybe
able improve patient’s global cognition through the use of ≤30-minute high intensity aerobic exercises ≤3 sessions per week for ≥16 weeks (Groot et
al., 2016; Zheng et al., 2016; Karssemeijer et al., 2017; Livingston et al., 2017; Du et al., 2018;
Jia et al., 2019; Law et al., 2020; Zhu et al., 2020).
Conclusion
It remains controversial whether physical
activity and exercise can prevent mild cognitive impairments and dementia or whether physical activity and exercise
can be utilized to treat the conditions.
Nevertheless, there is a growing body of evidence supporting this hypothesis that
an increased physical activity
and exercise level in the general population and the use of 30-minute high intensity aerobic exercises, 3 sessions per week for 16+ weeks,
will decrease rate of cognitive impairments and dementia. It is important to
note healthcare professionals or people considering this somewhat aggressive
approach must first address patient safety. Therefore, considerations should be
made for the patients current physical actively level, aerobic capacity, blood
pressure, oxygen saturation levels etc. In addition, the patient should be
closely monitored Pre, During and Post any exercise intervention.
Authors Information
- Thomas Wing BSc (hons), G.S.R, BASRaT-reg
- Facebook Page- Teesside Athletic Academy
- Instagram- @teessideathleticacademy
Reference List
- Hamer, M. and Chida, Y., (2009). “Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence”. Psychological medicine, 39(1), pp.3-11.
- Hopkins, W. G. (2019). Sportscience. [online] Sportsci.org. Available at: https://sportsci.org/ [Accessed 11 Apr. 2019].
- Hopkins, W.G. (2000). ‘Measure of Reliability in Sports Medicine and Science.’ Sports Medicine. 30, (1), 1-15.
- Sofi, F., Valecchi, D.,
Bacci, D., Abbate, R., Gensini, G.F., Casini, A. and Macchi, C., (2011). “Physical
activity and risk of cognitive decline: a meta‐analysis of prospective studies”.
Journal of internal medicine, 269(1), pp.107-117.
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Thank you Tom for this insightful post!
I am sure the readers have enjoyed this topic and given them plenty food for thought.
Andrew Richardson, Founder of Strength is Never a Weakness Blog
I have a BSc (Hons) in Applied Sport Science and a Merit in my MSc in Sport and Exercise Science and I passed my PGCE at Teesside University.
Now I will be commencing my PhD into "Investigating Sedentary Lifestyles of the Tees Valley" this October 2019.
I am employed by Teesside University Sport and WellBeing Department as a PT/Fitness Instructor.
My long term goal is to become a Sport Science and/or Sport and Exercise Lecturer. I am also keen to contribute to academia via continued research in a quest for new knowledge.
My most recent publications:
My passion is for Sport Science which has led to additional interests incorporating Sports Psychology, Body Dysmorphia, AAS, Doping and Strength and Conditioning.
Within these respective fields, I have a passion for Strength Training, Fitness Testing, Periodisation and Tapering.
I write for numerous websites across the UK and Ireland including my own blog Strength is Never a Weakness.
I had my own business for providing training plans for teams and athletes.
I was one of the Irish National Coaches for Powerlifting, and have attained two 3rd places at the first World University Championships,
in Belarus in July 2016.Feel free to email me or call me as I am always looking for the next challenge.
Contact details below;
Facebook: Andrew Richardson (search for)
Facebook Page: @StrengthisNeveraWeakness
Twitter: @arichie17
Instagram: @arichiepowerlifting
Snapchat: @andypowerlifter
Email: a.s.richardson@tees.ac.uk
Linkedin: https://www.linkedin.com/in/andrew-richardson-b0039278
Research Gate: https://www.researchgate.net/profile/Andrew_Richardson7